자료유형  

 단행본

Control Number  

0011629143

International Standard Book Number  

9781934115923 (hbk. : alk. paper)

International Standard Book Number  

1934115924 (hbk. : alk. paper)

International Standard Book Number  

9781597455541 (e-ISBN)

International Standard Book Number  

1597455547 (e-ISBN)

Library of Congress Call Number  

RM282.I44-T49 2009

Dewey Decimal Classification Number  

615.37-22

Title Statement  

Therapeutic antibodies : methods and protocols edited by Antony S. Dimitrov.

Publication, Distribution, etc. (Imprint  

New York, NY : Humana, c2009.

Physical Description  

xviii, 585 p., [8] p. of plates : ill. (some col.) ; 27 cm.

Series Statement  

Springer protocols

Series Statement  

Methods in molecular biology = 1064-3745 ; 525

Bibliography, Etc. Note  

Includes bibliographical references and index.

Formatted Contents Note  

완전내용Therapeutic antibodies: current state and future trends - is a paradigm change coming soon? / D.S. Dimitrov and J.D. Marks -- Preparation of recombinant viral glycoproteins for novel and therapeutic antibody discovery / Y.P. Chan ... [et al.] -- Design of a human synthetic combinatorial library of single-chain antibodies / L. Nahary and I. Benhar -- Construction of a human antibody domain (V(H)) library / W. Chen ... [et al.] -- Generation and selection of rabbit antibody libraries by phage display / C. Rader -- Construction of a large naive human phage-displayed Fab library through one-step cloning / Z. Zhu and D.S. Dimitrov -- Identification of target and function specific antibodies for effective drug delivery / Y. Zhou and J.D. Marks -- Screening of specific internalization Fab fragment from human naive phage library by combinational bio-panning / X. Wang and B.B. Cao -- Competitive antigen panning for selection of HIV-1 neutralizing human monoclonal antibodies specific for gp41 / M.Y. Zhang and D.S. Dimitrov -- Selection of non-aggregating V(H) binders from synthetic V(H) phage-display libraries / M. Arbabi-Ghahroudi, R. Mackenzie and J. Tanha -- Isolation of full-length IgG antibodies from combinatorial libraries expressed in Escherichia coli / Y. Mazor ... [et al.] -- Multiplexed flow cytometry: high-throughput screening of single-chain antibodies / J. Ayriss ... [et al.] --

Formatted Contents Note  

완전내용Human antibody repertoires / P.J. Meijer ... [et al.] -- Rapid screening platform for stabilization of scFvs in Escherichia coli / B.R. Miller, S.M. Glaser and S.J. Demarest -- In vitro antibody affinity maturation targeting germline hotspots / M. Ho and I. Pastan -- Affinity maturation by phage display / H. Thie ... [et al.] -- Production of chimeric heavy-chain antibodies / J. Zhang, R. Mackenzie and Y. Durocher -- Mammalian cell display for antibody engineering / M. Ho and I. Pastan -- Improving antibody binding affinity and specificity for therapeutic development / J. Bostrom ... [et al.] -- Construction and production of an IgG-like tetravalent bispecific antibody for enhanced therapeutic efficacy / D. Lu and Z. Zhu -- Deimmunization of monoclonal antibodies / T.D. Jones ... [et al.] -- Anti-CD22 onconase: preparation and characterization / D.L. Newton, L.H. Stockwin and S.M. Rybak -- Antibody-cytotoxic agent conjugates: preparation and characterization / R. Singh and H.K. Erickson -- High-level production of a humanized immunoRNase fusion protein from stably transfected myeloma cells / J. Krauss ... [et al.] -- Antibody fragment expression and purification / D. Dimitrova, V. Choudhry and C.C. Broder -- Scaling-up and production of therapeutic antibodies for preclinical studies / Y. Feng and D.S. Dimitrov -- Antibody production by the gram-positive bacterium Bacillus megaterium / E. Jordan ... [et al.] -- Neutralization of HIV by antibodies / I. Prado, T.R. Fouts and A.S. Dimitrov -- Dynamics of antibody domains studied by solution NMR / B.K. Vu ... [et al.] -- In vivo method for establishing synergy between antibodies to epidermal growth factor receptor and vascular endothelial growth factor receptor-2 / J.R. Tonra ... [et al.] -- Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in macaque models: experimental approaches / R.M. Ruprecht -- Organizing, exploring, and analyzing antibody sequence data: the case for relational-database managers / J. Owens.

Subject Added Entry-Topical Term  

Immunoglobulins Therapeutic use

Subject Added Entry-Topical Term  

Anticorps.

Subject Added Entry-Topical Term  

Antibodies, Monoclonal therapeutic use

Subject Added Entry-Topical Term  

Immunotherapy methods

Added Entry-Personal Name  

Dimitrov, Antony S.

Series Added Entry-Uniform Title  

Methods in molecular biology (Clifton, N.J.) ; v. 525.

Control Number  

ydul:91512

책소개  

With revenues from the top five therapeutic antibodies accounting for a majority of the recent pharmaceutical sales, the research and development in the field has exploded over the past several years and is expected to grow with new emerging monoclonal antibodies like Numax, Lucentis, Actemra, and others.